Abstract Danzhi Jiangtang capsule (DJC), a traditional medicinal formula composed of cortex moutan, heterophylly falsestarwort root, unprocessed rehmannia root, oriental waterplantain rhizome, dodder seed and leech, has been used to treat type 2 diabetes in clinic for almost 10 years. In addition, DJC was also confirmed that it could relieved oxidative stress of vascular endothelium in diabetic macroangiopathy. Based on the fact that the DJC could regulated the level of free fatty acids in diabetes patients and the constituents of DJC also possess potential anti-hyperlipidemic effect, thus, the present work aimed to evaluate the anti-hyperlipidemic effect of DJC and further investigated potential molecular mechanism of this action. As in vivo results revealed, DJC could reduced the levels of TC, TG, LDL, increased HDL level as well as decreased the level of ALT and AST of model rats. In addition, DJC also showed significant antioxidant effect by decreasing the level of MDA and increasing the level of SOD and GSH-Px. Furthermore, western blot analysis showed that DJC could up-regulated the expression of phosphorylated JAK2 and STAT3, and down-regulated the expression of SCOC3 protein, which indicated that DJC could regulate the metabolism of lipid via JAK2/STAT3 pathway.

The effect of rice straw biochar on soil nutrients was studied using a randomized block experimental design in atobacco-planting field, and differences in soil bacterial and fungal community structures were studied using high-throughput sequencing technology. The results indicated that the soil pH, CEC, total organic carbon (TOC), inorganic carbon (IC), soil total nitrogen (total N), total potassium (total K), available phosphorus (available P), and available potassium (available K) contents were all increased with the biochar application. TOC and available P contents increased by 38.19% and 22.38%, respectively, in the T2 treatment (4500 kg·ha-1 biochar) compared to those in control (CK). But the soil dissolved organic carbon ( DOC) and available nitrogen (availableN)content decreased by 13.07% and 9.89% in T2 treatments compared to the CK, respectively. Soil bacteria composition mainly consisted of Proteobacteria, Actinobacteria, and Acidobacteria, and the Proteobacteria proportion represented >50% of the bacterial community. The Actinobacteria proportion decreased, but Proteobacteria and Acidobacteria proportions increased with increasing biochar amounts. Fungi in tobacco-planting soils were mainly Ascomycota (>75%), but this proportion decreased as the biochar amount increased. However, Zygomycota and Basidiomycota proportions increasedwithincreasing biochar amounts. Therefore, biochar application could improve the soil nutrient status and affect microbial community structure. Rice straw biochar application promoted fungal community diversity in tobacco-planting soils.